Factores de riesgo asociados a defectos congénitos de genitales externos y gónadas masculinas

Introducción: Los defectos congénitos del tracto urogenital se encuentran entre las anomalías más encontradas en el feto o neonato, lo que da una idea de su extraordinaria importancia clínica, unido a las escasas investigaciones en la provincia Camagüey, sobre factores de riesgo asociados a los defectos congénitos de genitales externos y gónadas masculinas. Objetivo: Determinar los factores de riesgo asociados a defectos congénitos de genitales externos y gónadas masculinas. Métodos: Se realizó un estudio correlacional del tipo retrospectivo en el Hospital Pediátrico Eduardo Agramonte Piña en el periodo de enero de 2013 a diciembre de 2020. El universo se conformó por los 96 pacientes que fueron intervenidos quirúrgicamente por presentar defectos congénitos de los genitales externos y gónadas masculinas. Para determinar la asociación de los factores de riesgo con la aparición de defectos congénitos se empleó la prueba de independencia, en caso de p<0,05 se consideró asociación significativa. Para medir la magnitud de la asociación estadística entre las variables se utilizó el coeficiente Phi, se consideró mientras más fuerte a uno fuera su valor, más correlacionadas se encontraron las variables estudiadas. Resultados: La criptorquidia fue la forma clínica con mayor número de pacientes, seguida de la hipospadias y la hidrocele. La asociación entre los padres trabajadores agrícolas y la hipospadias y la criptorquidia con padres trabajadores industriales, resultaron significativas. El hecho que la madre fuera fumadora pasiva, constituyó una variable con asociación significativa, tanto para la aparición de hipospadias como de criptorquidia. El ser fumadora pasiva fue el factor de riesgo que tuvo mayor correlación con la aparición de los defectos congénitos. Conclusiones: Existieron factores de riesgo con asociación significativa a la aparición de defectos congénitos de genitales externos y gónadas masculinas.

Introduction: Congenital defects of the urogenital tract are among the anomalies most found in the fetus or neonate, which gives an idea of ​​their extraordinary clinical importance, together with the few investigations in the Camagüey province, on risk factors associated with congenital defects of external genitalia and male gonads. Objective: To determine the risk factors associated with congenital defects of the external genitalia and male gonads. Methods: A retrospective correlational study was carried out at the Eduardo Agramonte Piña Pediatric Hospital from January 2013 to December 2020. The universe was made up of the 96 patients who underwent surgery for presenting congenital defects of the external genitalia and male gonads. To determine the association of the risk factors with the appearance of congenital defects, the independence test was used; in case of p<0.05, a significant association was considered. To measure the magnitude of the statistical association between the variables, the Phi coefficient was used, it was considered that the stronger its value was, the more correlated the studied variables were found. Results: Cryptorchidism was the clinical form with the highest number of patients, followed by hypospadias and hydrocele. The association between farm worker parents and hypospadias and cryptorchidism with industrial worker parents was significant. The fact that the mother was a passive smoker was a variable with a significant association, both for the appearance of hypospadias and cryptorchidism. Being a passive smoker was the risk factor that had the highest correlation with the appearance of birth defects. Conclusions: There were risk factors with a significant association with the appearance of congenital defects of the external genitalia and male gonads.

Case for diagnosis. Atypical genital lesion

Abstract: We present a case of a penile lesion with a clinical appearance similar to Mondor penile disease (thrombosis of the dorsal vein of the penis) or penile sclerosing lymphangitis. Laboratory evaluation, however, showed a solid lesion, with no vascular component to Doppler ultrasonography and no treponema to immunohistochemistry. Histological and serological tests were compatible with secondary syphilis. The authors reinforce the need for the inclusion of syphilis in the differential diagnosis of penile cord injuries.

A wet dressing for male genital surgery: A phase II clinical trial

ABSTRACT Purpose: This study was to confirm the safety and efficacy of BC dressing when used in surgical male wound healing at the urogenital area. Methods: Open, non-controlled clinical study of phase II. A total of 141 patients, among those children, adolescents and adults with hypospadias (112), epispadias (04), phymosis (13) and Peyronie's disease (12) that had a BC dressing applied over the operated area after surgery. A written informed consent was obtained from all participants. Study exclusion criteria were patients with other alternative treatment indications due to the severity, extent of the injury or the underlying disease. The outcomes evaluated were efficacy, safe and complete healing. The costs were discussed. Results: In 68% patients, the BC dressing fell off spontaneously. The BC was removed without complications in 13% of patients at the outpatient clinic during the follow-up visit and 17% not reported the time of removal. In 3% of the cases, the dressing fell off early. Complete healing was observed between 8th and 10th days after surgery. The BC dressings have shown a good tolerance by all the patients and there were no reports of serious adverse events. Conclusion: The bacterial cellulose dressings have shown efficacy, safety and that can be considered as a satisfactory alternative for postoperative wound healing in urogenital area and with low cost.

Primary cutaneous histoplasmosis developed in the penis of an immunocompetent patient

A 70-year-old male presenting a 3-month history of genital painless erythematous nodules in the balanopreputial sulcus was referred to our service. Histopathological exam presented a chronic dermatitis with epithelioid granulomas and Grocott staining revealed numerous fungal structures with a suggestive morphology of Histoplasma sp. Cultures evidenced Histoplasma capsulatum var. capsulatum. Treatment with oral itraconazole led to complete remission of lesions.

Fratura de pênis com trauma uretra / Penile fracture with urethral trauma

We reported a case of a twenty-nine-year-old male who presented a penile fracture associated with urethral injury caused by a sexual intercourse. An ideal anamnesis and a special physical examination were determinant to correct diagnostics. Ultrasonography and uretrocistography must be performed for confirmation. The treatment is based on the presence of associated urethral injury. The surgical repair of cavernous body and urethra can produce good results, with a favorable prognosis and minimal rate of complications.

Plástica do púbis e da genitália externa: duas décadas de experiência / Plastic of the pubis and external genitalia: two decades of experience

Este artigo registra a experiência de duas décadas de cirurgias realizadas na região do púbis e da genitália externa em pacientes de ambos os sexos. A literatura apresenta limitadas contribuições sobre as alterações morfológicas que têm levado seus portadores a se submeterem a cirurgias para retornarem à normalidade anatômica, ao equilíbrio emocional e a recuperarem a autoestima. Método: Foram operados 513 pacientes com diferentes tipos de patologias nos genitais externos e no púbis, num período de vinte anos, sendo 469 (91,42%) do sexo feminino e 44(8,58%) do sexo masculino. A idade variou de 17 a 70 anos. No sexo feminino, as deformidades mais frequentes foram as distrofias do púbis, grandes e pequenos lábios, prepúcio sobre o clitóris, além das distorções secundárias decorrentes de cirurgias realizadas previamente nestas regiões. No sexo masculino, as afecções mais frequentes envolveram a região pubiana, hipotrofias penianas, sinéquias e ausência de testículos. Deformidades congênitas, além das descritas, não foram incluídas no presente artigo. Resultados: Durante o período de 1989 a 2010, os procedimentos aplicados nas disformias pubianas e nas genitálias beneficiaram pacientes física e psicologicamente, pela qualidade dos resultados e pelo baixo índice de complicações (2,31%). Conclusões: Apesar da limitada divulgação científica nas revistas da especialidade e nos eventos científicos, a importância destas patologias não tem limite nos seus portadores. Uma das razões da presente publicação baseia-se na experiência adquirida e a necessária divulgação aos especialistas que realizam estas cirurgias, face às consequências que determinam quando não executadas dentro da necessária realidade.

This article is the result of two decades of surgical experience in the pubic region for patients of both genders with the external genitalia dimorphic aspects. The literature presents limited contributions regarding the morphologic alterations of these regions, responsible for the patients be submitted to these surgeries to return to their normal anatomic aspects, to the emotional equilibrium and to the self-esteem. Methods: Patients of both genders, in a total of 513, with different types of pathologies of the external genitalia and the pubic regions were submitted to specific surgeries, where 469 (91.42%) were female and 44 (8.58%) were male. The age range was from 17 to 70 year old. In the female patients were included: dystrophies of the pubis, labia majora and minora, skin excess of the clitoris, and the treatment of other types of unacceptable results after previous surgical procedures. The male deformities included in this study were: penis hypotrophy, skin penis synechia, local angioma and the absence of congenital testicular glands. Congenital or acquired deformities out of the described were not included. Results: From 1989 to 2010, the procedures used in the genitalia and in the pubis dimorphisms brought psychological and physic benefic to the patients combined with low complication rate (2.31%). Conclusions: Despite of the limited scientific publications in the journals of the specialty and in the scientific meetings, the importance of these messages has no limits to their holders. One of reasons of this publicationis based in acquired experience and the necessary diffusion for those that perform these surgeries but still with negative results when not performed within the necessary level.

Investigation of male urinogenital clue cell and its relationship with male infertility / 中国医师杂志

Objective To investigate the relationship between clue cell in semen and male infertility. Method Semen specimens from 957 patients were examined with microscope. Gram staining was performed when clue cell were found to be present in semen. At the same time, general characteristics of the sperm were analyzed. Results There were clue cells in 23. 5% (225/957) of the total specimens, in which, 95. 1% clue cells were gram staining positive. The concentration and vitality of living sperm in semen presented with clue cell were significantly lower, but the abnormal sperm and pH value were much higher than that in normal control (P<0.01). In addition, 28 sexual partners of 30 infertility patients were identified as having bacterial vaginosis. Conclusion Gardnerella vaginalis and short coccohacillus were mostly transmitted from infected sexual partner. It could cause squamous epithelial cell forming clue cell, and lead to infertility by chan-ging pH which mainly affect reproduction of the sperm. This study suggested that clue cell has a unique vale for the diagnosis of infertility causing by Gardnerella vaginalis and short coccohacillus.